KEGG   Homo sapiens (human): 11200
Entry
11200             CDS       T01001                                 
Symbol
CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, TPDS4, hCds1
Name
(RefSeq) checkpoint kinase 2
  KO
K06641  serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04115  p53 signaling pathway
hsa04218  Cellular senescence
hsa05166  Human T-cell leukemia virus 1 infection
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
  Element
N00455  CDC25-Cell cycle G2/M
Disease
H00020  Colorectal cancer
H00036  Osteosarcoma
H00881  Li-Fraumeni syndrome
H02624  Tumor predisposition syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    11200 (CHEK2)
   04115 p53 signaling pathway
    11200 (CHEK2)
   04218 Cellular senescence
    11200 (CHEK2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    11200 (CHEK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    11200 (CHEK2)
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    11200 (CHEK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     11200 (CHEK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  RAD53 family
   11200 (CHEK2)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    11200 (CHEK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr FHA Kinase-like Kdo ABC1 Haspin_kinase YrbL-PhoP_reg Pkinase_fungal RIO1 APH
Other DBs
NCBI-GeneID: 11200
NCBI-ProteinID: NP_009125
OMIM: 604373
HGNC: 16627
Ensembl: ENSG00000183765
UniProt: O96017
Structure
Position
22:complement(28687743..28741834)
AA seq 543 aa
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
NT seq 1632 nt   +upstreamnt  +downstreamnt
atgtctcgggagtcggatgttgaggctcagcagtctcatggcagcagtgcctgttcacag
ccccatggcagcgttacccagtcccaaggctcctcctcacagtcccagggcatatccagc
tcctctaccagcacgatgccaaactccagccagtcctctcactccagctctgggacactg
agctccttagagacagtgtccactcaggaactctattctattcctgaggaccaagaacct
gaggaccaagaacctgaggagcctacccctgccccctgggctcgattatgggcccttcag
gatggatttgccaatcttgaatgtgtgaatgacaactactggtttgggagggacaaaagc
tgtgaatattgctttgatgaaccactgctgaaaagaacagataaataccgaacatacagc
aagaaacactttcggattttcagggaagtgggtcctaaaaactcttacattgcatacata
gaagatcacagtggcaatggaacctttgtaaatacagagcttgtagggaaaggaaaacgc
cgtcctttgaataacaattctgaaattgcactgtcactaagcagaaataaagtttttgtc
ttttttgatctgactgtagatgatcagtcagtttatcctaaggcattaagagatgaatac
atcatgtcaaaaactcttggaagtggtgcctgtggagaggtaaagctggctttcgagagg
aaaacatgtaagaaagtagccataaagatcatcagcaaaaggaagtttgctattggttca
gcaagagaggcagacccagctctcaatgttgaaacagaaatagaaattttgaaaaagcta
aatcatccttgcatcatcaagattaaaaacttttttgatgcagaagattattatattgtt
ttggaattgatggaagggggagagctgtttgacaaagtggtggggaataaacgcctgaaa
gaagctacctgcaagctctatttttaccagatgctcttggctgtgcagtaccttcatgaa
aacggtattatacaccgtgacttaaagccagagaatgttttactgtcatctcaagaagag
gactgtcttataaagattactgattttgggcactccaagattttgggagagacctctctc
atgagaaccttatgtggaacccccacctacttggcgcctgaagttcttgtttctgttggg
actgctgggtataaccgtgctgtggactgctggagtttaggagttattctttttatctgc
cttagtgggtatccacctttctctgagcataggactcaagtgtcactgaaggatcagatc
accagtggaaaatacaacttcattcctgaagtctgggcagaagtctcagagaaagctctg
gaccttgtcaagaagttgttggtagtggatccaaaggcacgttttacgacagaagaagcc
ttaagacacccgtggcttcaggatgaagacatgaagagaaagtttcaagatcttctgtct
gaggaaaatgaatccacagctctaccccaggttctagcccagccttctactagtcgaaag
cggccccgtgaaggggaagccgagggtgccgagaccacaaagcgcccagctgtgtgtgct
gctgtgttgtga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (4)   
   KEGG PATHWAY (4)   
Network (2)   
   KEGG NETWORK (2)   
Disease (8)   
   KEGG DISEASE (4)   
   OMIM (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (37)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (35)   
DNA sequence (101)   
   RefSeq(nuc) (43)   
   GenBank (29)   
   EMBL (29)   
3D Structure (38)   
   PDB (38)   
Protein domain (11)   
   Pfam (11)   
All databases (228)   

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